The missing LINC

Build a braveheart: the missing linc (RNA).

The Missing LINC for Genetic Cardiovascular Disease?

As of 2014, cardiovascular disease (CVD) was listed as the underlying cause for 1 of every 3 deaths in the United States. Many forms of CVD have a strong genetic component, and the number of causal genes elucidated greatly depends on the type of CVD under study. Understanding the molecular basis of CVD can guide medical decisions of the practitioner, patient, and family members. Currently, gene...

Noncoding RNAs: The Missing “Linc” in p53-Mediated Repression

The tumor suppressor protein p53 coordinates the cellular response to stress through regulation of gene expression. Now, Huarte et al. (2010) identify a long intergenic noncoding RNA as a new player in p53-mediated repression of genes involved in apoptosis.

To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer

Colorectal cancer (CRC) is the third most frequent cancer and one of the leading causes for cancer-related mortality. Aberrant activation of the Wnt signaling is an essential initiating factor in colon carcinogenesis, and a driving force of CRC progression. Recently, long non-coding RNAs (lncRNAs) have emerged as significant players in CRC pathogenesis through diversified mechanisms. Although b...

TorsinA regulates the LINC to moving nuclei

How LINC complexes are regulated to connect nuclei to the cytoskeleton during nuclear migration is unknown. Saunders et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201507113) show that the AAA+ ATPase torsinA and its partner LAP1 are required for nuclear migration during fibroblast polarization by mediating the dynamics of LINC complexes.